Sorry to hear about the recent issues you have been experiencing.
Uninstall your RME drivers. Download the latest driver for your device, and reinstall it to a new USB port if it is the USB version. As we may need more information that the answers system is capable of, if the issue remains, please submit a ticket to support.
Here is a link to create a ticket: http://support.presonus.com/hc/en-us/requests/new