Sorry to hear about the recent issues you have been experiencing.
This does sound like the CPU is being put under a bit of strain, the buffer may be set too low.
Here are some basic trouble shooting steps:
1. Please make sure Windows is optimized: https://www.sweetwater.com/sweetcare/articles/pc-optimization-guide-for-windows-10/
2. Set Options > Audio Setup > Processing > Dropout Protection to Maximum. This is a new feature that is very powerful. I recommend reading up on DropOut Protection in the Studio One Reference Manual.
3. If you open the performance monitor in Studio One, you can view the resources that are being used by each of your plug-ins. See if you can find a particular plug-in or set of plug-ins that might be causing the issue.
This may be bit more involved than what the Answers system is intended, so please create a support ticket to discuss this in more detail.
Here is a link to create a ticket: http://support.presonus.com/hc/en-us/requests/new