I'm having the same issue with Melodyne after uploading Studio One 4. On a given song file, the first time Melodyne is activated the entire right-hand side of the Melodyne window is cut off, thus preventing access to the top right-hand corner icons (minus sign, square[s], and X). Then, upon opening Melodyne a subsequent time in the same song file, the Melodyne window is complete but fills only have the screen (left), and the right side of the Melodyne window is a grey/black square. I've reported this issue to PreSonus, and I've been told that its development team is aware of the problem. I suggest that anyone having similar issues to submit a work request to PreSonus ASAP!