I have been having on reoccurring issue with studio one though. Every time i open studio one i am unable to then hear anything off my computer. Whether it be a video on Youtube, sound-cloud, or playing some beats off my desktop. I tired changing the setting to window in the audio advanced bar off of studio one, but it still doesn't work. The only way i can hear anything off YouTube again is when i close Studio one, and even then sometimes it doesn't work, and i have to reset, or unplug my interface and re-plug it.
I am currently using a zoom R16 interface, and have a windows Desktop.