I have the same Problem with Studio One 5.
Windows 10 Pro x64, Soubdblaster X-Fi. Nothing else attached. When starting Studio One it stops at "Startig audio engine" and then nothing happens for afew seconds. Then Windows shows the Bluescreen with DPC Watchdog violation.
Since your Post is from 2019 with no answer, it seems that there is no solution to this Problem?!