You say that you are doing a Podcast but you don't say what software you use nor what you are trying to record with.
The AudioBox is designed to record and play audio at the same time. You will need headphones and or monitor speakers connected to the Audiobox itself.
Turn the Mixer Dial all the way to the LEFT. You should hear only input audio. If so, you know your mics and the AudioBox is working.
Ensure you have installed the current device drivers for the AudioBox.
If you still have trouble past this, contact PreSonus Support for further assistance.