This is not possible to answer.
It depends on many different factors, like how efficiently the different plugins are programmed, your audio equipment, operating system and driver versions, just to name a few.
As a rule of thumb, if you're on a Mac, try using the Audio Units (AU) version and see if this works as expected, monitor your CPU and memory usage when using the plugin, then try loading the VST 2 and 3 versions and repeat the process.
Choose the one that uses the least resources and feels most stable.
This is THE ONLY way to know what version of a given plugin that works "best" on your specific machine configuration, operating system version, and various hardware. There are so many factors, that it isn't possible to give an answer that covers every single plugin.
Think of plugins as "mini applications" running inside your DAW. Like the programs you use outside of the DAW environment, some programs suck, and others are well implemented.
VST Audio plugins claiming to be VST3 are also sometimes just "wrapped" in a VST3 container, and the actual code is written using the VST2 version frameworks. There is also a myth that VST3 is superior to VST2. Sometimes they are, sometimes they're not.
I work as a software developer, so I know a thing or two about how these things work under the hood, there is no single right answer to this question, and anyone that tries to convince you that it is, doesn't know anything about programming audio applications or plugins.