Here is how I would trouble shoot no audio output when using StudioOne. First, select the "options" tab under "studioone" heading at the top. Then click audio settings, and ensure that the audio device is what you intend to play music through and that it is hooked up to your speakers - and that speakers are turned on. Then I'd click the "mix" tab at the bottom and go to the channel for main output and ensure that it does NOT read "none" but rather refers to the left and right channels of the audio device that you selected under the audio settings tab. I hope that helps.