There are a few things that should be taken into account though when using low latency monitoring with high dropout protection.
Instruments using synced internal effects, arpeggiators, step editors, sequencers, gaters, modulation effects etc. will temporarily be out of sync when monitored.
Multi channels with effects...
When monitoring a track that is connected to an Instrument with multiple output channels containing inserts on each channel can lead to temporary high CPU load because all channels will be monitored in the low latency path.
When layering sound...
Monitored Low latency Instrument tracks are not 100% in sync (sample accurate) with the non monitored tracks. So be sure to disable monitoring when editing layered audio results, else result will differ from what you hear in the final mix.
> 3 ms inserts act differently depending on the monitoring path.
Monitored Instruments won't be processed by inserts with a latency > 3 ms. So for instance a limiter with 4 ms latency on your master bus will process any non-monitored instrument channel, but won't process monitored instrument channels.