Sadly system DPI scaling does not work with Native Instruments Kontakt in Studio One. This is especially an issue because the Kontakt GUI is mini sized in Studio One and hard to read at higher resolutions, unlike in some other DAWs which upscale it correctly depending on Windows scaling settings.
So I'd like to request this feature/bug fix, a focused fix on scaling so that it works in particular with Native Instruments Kontakt, the most widely used by overwhelming numbers software sampler around.