There is a known issue with the one particular Startech firewire card. The card has a Texas Instruments chipset, which is what we recommend, but the specific chip component is "not" compatible with Windows 10. Specifically the XIO2200A chip.
This is what Startech has to say.
If this is the card you have, then you need only get a new firewire card and check the vendor website for Windows 10 compatibility.
For FireStudio and classic mixers, we always recommend a firewire card that only has s400 speed 1394a connections with a Texas Instruments chipset.
You can attempt to Uninstall in the typical way, but also follow these instructions.
Uninstall in the typical way but also do this.
> Disconnect the FireStudio from your computer.
> Right click your Start menu and select "System".
> Click "Advanced System Setting" to the left.
> Click Environment Variables button.
> Click the New button for the top section on this window.
> For "Variable Name:" type this exactly.
> For "Variable Value:" enter a single number " 1 ".
> Click OK and couple times and then open the Device Manger.
> Click the View menu and check "Show Hidden Devices".
> Right click and Uninstall any "FireStudio", "PreSonus", "USB Audio Device" and or "Unknown Device" you see listed under any category.
> Restart your computer.
Then download and install these.
You may need to use this article to manually set the device driver.
Once installed, run Universal Control. Click the Settings menu. Check Firmware and Factory Reset.