Universal Control is "integrated" into Studio One. The UC says Bypass, it means the features are integrated into Studio One.
Ensure you have the current version of UC and Studio One installed.
You must have UC open and running "before" running Studio One to be properly integrated.
You can use UC mixes with Studio One "without" being integrated.
Open the Audio I/O Setup in Studio One and "uncheck" Cue Mix for Outputs.