I was using my 16.0.2 USB with my DAW (Cakewalk Sonar 8.5) successfully, playing back and recording audio.Suddenly playback stopped and an error message appeared which said something like the selected audio device cannot play back this kind of audio.
I restarted everything and now the computer does not show my Presonus mixer as an audio device at all. I have swapped out USB cables and USB ports and I have reinstalled Universal Control.
The mixer lights up and works as a standalone mixer. Meaning, I play my bass guitar into it and sound comes out of my speakers.