You can't search on a page of the "Studio One Reference Manual"
You can search on the page of a PDF.
Search capabilities of "Studio One Reference Manual" are mediocre
Search capabilities of PDFs are superior.
You can't print the "Studio One Reference Manual"
You can print a PDF
You can't use accessibility features "Studio One Reference Manual"
You can use accessibility tools with a PDF, such as voice reading.
You can't annotate; highlight or underline words or sentences of the "Studio One Reference Manual"
You can annotate, highlight and underline words or sentences of a PDF.
When you select the Presonus Window, the "Studio One Reference Manual", possibly on monitor 2, gets into focus.It is a pain when you have a video/web tutorial on monitor 2. You follow it, select Presonus window to try, and bam it is hidden by the manual.
A PDF does not change its focus depending on another application.