I am sort of at my wits end with this problem. I have watched a few videos and made sure my sample rates match, I have changed them between 48k and 41k and nothing seems to work. I want to be able to record from my Scarlett Solo audio interface and have playback trhough headphones connected to my PC. I honestly have no idea what else to try. I have double checked my sample rates and it does not seem to matter, Studio One always fail to open my microphone. Any help? I was hoping this would be more plug and play but it appears it is not which is alittle disheartening.