I run Logic Pro X on a MacMini with an Audiobox USB 96 interface. Worked fine until I upgraded the OS to 10.14 Mojave. It worked fine in 10.13 High Sierra. The computer and DAW still see it the Audiobox, but wasn't getting audio from it. I followed the PreSonus recommended actions (Microphone setting and update UniversalControl)...
Now, upon a reboot I can get sound through it, though there is an unreasonalbe amount of noise. If I pull the inputs all the way down, there is still a significant amount of noise being registered with the DAW, but not coming through the headphones (and I did adjust the mix knob to check). If I hit record, it's just noise and a faint click. If I try adjusting the DAW settings (like the sample rate or input/output), it just fails to get anything from the Audiobox until I reboot.
I haven't tried a reinstall of Mojave yet, but I'm tempted to revert back to High Sierra unless anyone has any other troubleshooting steps that I should try.