Here is a link to the PreSonus compatibility statement for MacOS 10.14 (Mojave)
https://support.presonus.com/hc/en-us/articles/360006825371--Apple-MacOS-10-14-Mojave-compatibility-statement
you have to give permissions to studio one to access your microphone after mojave installation
https://support.presonus.com/hc/en-us/articles/360016467411-Why-am-I-not-able-to-record-in-Studio-One-after-upgrading-to-Mojave-