You will want to make sure that you have the latest driver installed for your 1818. Here is a link:
http://www.presonus.com/support/downloads/AudioBox-1818VSL
You may also want to try re-installing Studio One and removing your settings from the program. Here are instructions for removing the settings:
1. Go to Help>Open Settings folder.
2. Copy the contents of the folder over to a folder on your desktop.
3. Close S1 and delete the contents of the settings folder with the exception of the user.license file as well as the "Extensions" folder.
4. Open S1 and go to Studio One>Options (Preferences on a Mac) to reconfigure your settings.
5. Test to see if the problem is resolved. If it is not, please feel free to copy your settings files back over from the backup that you created in step 2.
*If you are missing presets or Sound Sets after doing this, simply double-click one of your Sound Sets under Documents>Studio One>Sound Sets.
