According to page nine of the manual, yes. The usb connection can be used as an audio interface with the correct drivers. Quote:- 5 USB TO HOST connector
USB connector used to connect the console to a
computer, allowing the console to function as an audio
interface. Supports input and output for 34 channels
of 48 kHz, 24-bit audio. When using with a computer
running Microsoft Windows, the Yamaha Steinberg
USB Driver is required. When using a Mac, Core Audio
is used and therefore no extra drivers are required.
