Studio One devs need to prioritize developing support for Izotope RX Connect.
The RX Connect workflow is well established as an industry standard.
Either functioning with ARA, similarly to the Melodyne integration. Audio> Edit with RX, or The ability to edit selected waveform(s) in an External editor. Audio> Edit in External Editor. I just switched over to Studio One for music, with a background in Pro Tools, Reaper, Cubase, and a glaring problem that all the other DAWs have sorted out, is RX Connect integration.
This is particularly frustrating because on the official Izotope RX 10 System Specs page it lists compatibility with Studio One, which is misleading. If there is no plan to support RX, Presonus should consider contacting Izotope to clarify that only the plugins from RX are valid in Studio One, but specifically not RX Connect, and not RX Monitor. Equally as useful is officially communicating that RX Connect/Rx Monitor are not supported, as searching about this topic either in forums or in the manual it is not immediately clear that Presonus has not developed functionality for RX Connect. As a customer, I found the lack of information about RX Connect as a point of frustration and a poor time investment.
I do see this request has been made previously many times, and the top link that Feature Request suggested I looked at was posted in 2015, which was now 8 years ago.
It looks like the best workflow with RX is actually a hack that is outlined here: https://forums.presonus.com/viewtopic.php?t=36233&p=212444
All the best, big fan of the product, and can't wait for proper RX Connect functionality to be implemented in Studio one!