In my testing on both Mac and PC, using S1 Artist and S1 Pro, the PC works well but there are a few banking issues where the mixer does not update right away. But it is usable.
On a Mac however it is not reliable at all. I have tested every mode and it just does not update correctly in any version of Studio One.The OS is Windows 10 but I also tested 7 and 8 as well as Studio One V2 and V3.
Below are 2 videos I did showing how to set it up and all the working functions on a PC
Hope this helps.