1. Please try increasing your ASIO buffer size for your audio interface in the control panel for the AudioBox iTwo prior to opening Cubase. See if a higher ASIO buffer size/Device Block Size puts less strain on your CPU.
2. Please make sure Windows is optimized for pro audio: https://www.sweetwater.com/sweetcare/articles/pc-optimization-guide-for-windows-10/
3. Check in Cubase to see if a particular plug-in or plug-ins is causing this issue. If you identify a problematic plug-in, see if you have the option to disable multi-processing within that plug-in.
If none of the above helps, please submit a support ticket. please create the ticket and include the following requested files.
You can help me get a better view of your hardware configuration by sending back the following requested files:
You will need to have your AudioBox iTwo attached to the computer by USB and powered on when you do this.
1. Please send me your computer's System Info file.
To access your PC’s System Information on Windows 8 and Windows 10:
1. Go to the Desktop.
2. Press [WinLogoKey] + R to bring up 'Run'.
3. Type 'msinfo32' without quotes.
4. Press the [Enter] key.
5. IMPORTANT: Click File then "Save as", save this file as a .nfo file
format and rename the file your name and attach it to this email.
IMPORTANT: "Save as" type: System information File (*.NFO) and attach it to the reply of the ticket.