Question

Computer = ASUS ROG GL752VW-DH71 17.3-inch Gaming Laptop (Intel i7 2.6GHz, 16GB DDR4 RAM, 1TB HDD, GTX960M 2GB Graphic Card, Windows 10)

PreSonus AudioBox1818 VSL- Advanced 18x18 USB 2.0 recording interface

Studio One Artist (came with 1818)

I tried re-installing 1818 driver and selecting

Answer 1

See if you can go in and select no device, then apply, then select the 1818, then apply. Switching devices sometimes will reset the audio engine.

It may be a good idea to open a support ticket also.