Here's something to avoid doing during a Live performance or Recording session when using a PC:
When any mixer is connected to PC and the mixer name is changed in the UC launch window while firewire audio is playing, the audio mutes and sometimes can sometimes become distorted.
*This issue occurs in all UC versions when playing back Firewire Returns from the PC.
The audio mutes for a second and can then be heard. When it umutes, it can sometimes be distorted and the only way to stop the distortion is to either quit the audio playback program or rename the mixer again.
*Note: This only happens with firewire audio playback and does not happen on Mac OSX.
http://support.presonus.com/entries/21351074-Changing-Mixer-Name-in-VSL-Pauses-Distorts-Audio