Here is a good discussion from the old Studio One forum on this subject: http://forumsarchive.presonus.com/posts/list/45798.page
Learning the elements of a good Fuzz sound, like from the perspective of a certain artist sound you want to emulate would be a good starting point. Then you can use the built in efx in Studio One to put together a good guitar efx chain.
In Ampire, using the Tube Driver with the Equalizer, and the basic knob controls, you should be able to get pretty close with out having to add third party VST support.
However, I definitely recommend adding VST support to Artist: https://shop.presonus.com/products/software/studio-one-add-ons/VST-and-AU-and-Rewire-Support
That would open up your choices for all the free and paid third party VST guitar effects.
We also encourage you to create a thread about this on the Presonus user forum. https://forums.presonus.com/viewforum.php?f=108
This will allow for back and forth discussions about an issue or question and more points of view as to possible different approaches or workflows.