Just bought a new Mobile 192. Have spent all morning trying to figure this out. Had the same problem with my Scarlett 8i6. Changing the sample rate to 441000 Hz (studio quality) on the 192 cleared it up.
To change this, right click on the little speaker icon lower right side of screen near clock. Click "Open Sound Settings."
Select "Sound control panel" on right side under related settings.
Under Playback tab, highlight your playback device (in my case HP L/R Studio 192 Mobile)
Right click the device highlighted. Click "properties" then select the advanced tab.
Use the dropdown menu to select the sample rate. Hit Apply.
Windows audio (YouTube videos, iTunes, etc.) will now all play with Studio One open. Did not make other changes suggested. In fact, when I followed the directions on the screenshot, got the same result as jarrettrenshaw1 Had to open task manager and "end task" for S1 to get out of the program.