I have the AudioBox iOne connected via USB to the latest iMac 27" (5K retina) with 32GB RAM
Just installed High Sierra 10.13.1
Running Universal Control 22.214.171.124619 OSX x64 (I also tried 2.4.x but no luck).
Just trying to get basic audio out (iTunes) but I'm getting nothing. Internal speakers work but not the AudioBox.
The interface was working under 10.12.x