It would be cool if S1 had a user definable option to upsample plugins on transform and render. This would be helpful when it comes to synthesizers and effects that produce aliasing (amp sims, distortions, compressors, EQ's, tape sims, etc.) and other unwanted effects as frequencies approach or exceed the nyquist frequency in order to reduce the amount of aliasing (i.e. improve sound quality). The idea is that your project might still be at 44.1khz, but on render, the plugins would function as though they were running in a 88.2khz project so you'd have less aliasing and fewer artifacts (like EQ curves crinkling near nyquist).
I envision a box, that would be added to the render windows asking the user if they want to upsample, and if checked, the appropriate upsampling and conversion back down to normal would occur. If the user didn't want to use this feature, then they would obviously just leave the box unchecked.