I recently upgraded my Mac Mini to Catalina with zero problems. Prior to upgrade I checked to make sure all my apps were 64-bit, and Studio One is. Just today I installed an update to Catalina, 10.15.4, and afterwards I got a "Legacy System Extension" warning that a system extension loaded by PreSonus Software Limited will be incompatible with future versions of macOS. I'm good for now, but hopefully PreSonus will make the necessary updates to keep up.