There are many different ways you can do this. We can certainly lend some advice, however the final configuration is up to you.
The Quantum 4848 has 32 Line Inputs via 25 Pin connectors, it also has 2x sets of ADAT connectors for another 16 channels for a total of 48 In and 48 Out. You could purchase two Digimax DP88's which also feature 25 Pin connectors to complete your setup with just one Q4848 and 2x DP88's or you can get 2x Q4848's and cascade them together, that would give you full fader control over inputs to the computer.
The art of the patch bay is the most complex part of any studio, it is THE heart of your studio. You'll need to do some planning ahead of time. You need to fully understand the differences between Normal, Half-Normal and Straight Through. Examples of how patchbays are wired can be found in this article from Sweetwater - https://www.sweetwater.com/sweetcare/articles/how-to-use-a-patchbay/.
Consider getting a patch bay to route to console inserts with your outboard gear (1176's, etc) wired either straight through, normalled, or half-normalled. Preferablly using TT patchbay with solder or punch down connections. Using Half-Normal or Normal has outboard effects always routed to certain channels, repatching will allow you to send it to other channels or have other channels feed those inputs.
Also remember, you have a master bus section with inserts and Aux's for each bus and the master output with inserts as well. You'll need to figure that into your design as well.
Connecting the Quantum is as easy as 25 Pin Out from Q4848 to Line Input on console and 25 Pin In from Direct Out of Console.
Now you have some options:
However this leaves your Mic Pre Inputs still open. You may want to create a remote connection panel below your insert patch bay to get easy access to the XLR's, again solder those XLR cables to what is plugged into the back of the console.
With some reading and careful planning using a Google Sheet, Excel or just a piece of graph paper and a pencil you can figure this all out ahead of time. Doing this will save you a huge headache later. Even if you chose not to go with our solution, you'll still have to do this.
The PatchBay is the last piece of gear to change in any studio. It will outlast all other gear. I have patchbays that I've had for 20 years in my rig. And have soldered my fair share of permanent installs.
If this all seems a bit much, it can be, you may want to consider hiring an audio professional to help you plan this all out.
Good luck with your studio build.
I took a picture of the patchbay in the PreSonus Studio:
