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Cracking and artifacts with Studio One 5 while playing virtual Instruments!

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asked Oct 1 in Studio One 5 by tibifiers (180 points)
I have an issue and it's driving me mad. When playing any virtual Instruments within Studio One 5, I'm getting popping, cracking and distortion here and there, especially on certain notes and melodies and when there's lots of notes, it seems to happen more. Basically, artifacts are introduced like a bad signal or something. Or bad cabling. Everything is new.

I've tried changing buffer settings. The high setting has too much latency but still does it. The one just under that is good with latency but crackles . There's no middle ground that works for me.  I've tried many different VSTs and it's the same thing. It's horrible and puts me off when playing my MIDI keyboard. M-Audio Pro 49.

I have an Asus i7 2.4Ghz (goes up 3.4ghz), 16GB RAM and it's an SSD. I have a PreSonus Studio 26c with Yamaha HS7s.  There's no reason I know that it should be doing this with this laptop. My other DAWs were perfectly clean and smooth sounding. Zero issues. I don't get it at all. It's infuriating trying to get to the bottom of it.

I've got work to do. Please help!! What could it be? What else could I try?? Thanks in advance. Look forward to your reply.

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