Hi there.
Have you tried different block sizes? I have Presonus Studio 192 interface and if I am using a virtual instrument I get pops and clicks running anything less than a block size of 512. I tend to use a higher block size of 1024. You should be able to change these settings via the Universal Control software or when you go into the settings while Studio one is open. On Windows, from the start page click "configure audio Device". Once the options are in front of you then you need to select Audio Setup and audio device. (If you're on Mac, I cant help any further.
Also, while I think of it make sure you're not connecting the audio device to a Thunderbolt hub, but using a Thunderbolt connected directly to the motherboard.