I have an HP laptop with TB and the Quantum works fine there. This seems to be a specific issue with the Lenovo P52...so I know the Quantum, cable, and adapter are good.
Having major sound quality issues with the new Quantum. Windows system sounds are crackling/popping on playback with zero other software running and near zero CPU load. Youtube playback is initially crystal clear then after 20 seconds gets major crackles/pops. Same behavior over mains and headphone output. Took buffer to 2048, no change. Changed process priority for TB and UC to High and Realtime, no change.
Coming from a Scarlet 6i6 2nd Gen USB which ran with no issues on the same system. DPC latencymon is amazing (all green, no issues) and was running great via USB. I needed more I/O hence the upgrade to Quantum.
New install of Quantum TB interface. Updated Win10, TB firmware, TB drivers, and latest Presonus Quantum software/drivers. Nothing else has been installed on the computer software-wise other than Ableton 10. Strictly audio PC usage. Not sure if its the Lenovo TB implementation, the Quantum hardware, my Startech adapter, or some other config. I running about as pure Win10 install as one can get.
Startech Adapter TBT3TBTADAP