If it's the M1 silicon chip in the mac it's not compatible.
https://support.presonus.com/hc/en-us/articles/360051407452-Apple-Silicon-M1-Computer-Compatibility
If it's a 16.0.2 USB it would be best to create a support ticket.
https://support.presonus.com/hc/en-us/articles/210050813-How-to-create-a-new-Support-Request-