Same here, it's a critical fail on engineering of Studio One, come from V3. I have a lot of instruments with USB connection, when need to play some of this, need to power-on or plug in the USB cable, and crash Studio One...
Latest work on Presonus are more focusing on subscription marketing, but don't working in fix various serious issues.
I was move form Steinberg when Cubase 7 convert on a toy... now Studio One, go for the same way...
Windows 10 64 bits, Intel i5-9600K @ 3.70GHz, 32 Mb of Ram. RTX 2060 16Gb