1. Have you tried raising the buffer setting?
2. Is the AudioBox directly connected to the computer or through a USB Hub? If it is on a hub, please try connecting directly to the computer via a rear USB port.
3. Also, please try installing the AudioBox on a different USB.
5. If possible, temporarily install Universal Control and attach the AudioBox on a different computer to see if the issue reoccurs there.
If the issue persists, please create a support ticket.