I have got the same exact problem.
Even when my Skype and other audio dependent programs start when booting up Windows, It'll make that clicking sound.
When i open up my FL Studio 12 and loading plugins same thing.
I've tried to reinstall the driver (and tried all my usb ports). Disabled powersaving on my usb hubs after following this guide:
http://www.presonus.com/community/learn/Optimizing-Windows-Vista-and-Windows-7-for-Music-Production
Windows 7 64bit
Asus MAXIMUS VII Ranger Motherboard
Intel Core
[email protected]
16GB RAM
Audiobox iTwo
Universal Control 1.8.1