One way to utilize this type of product is by using the DB25 direct out connections on the back of the 16.4.2AI mixer. Just connect 2 DB25 to TRS snakes (8 channels each) to each respective input on the PowerPlay16 and then you will have a pre-EQ/Dynamics send of all the channels on your 16.4.2AI that can be individually mixed.
If you wanted to use the AUX outputs you would only need to connect TRS cables from the Aux outputs on the 16.4.2 directly into the TRS inputs of the PowerPlay distribution. To get signal, you would first need to create an Aux mix. Please refer to your user manual for instruction on creating an aux mix on the StudioLive 16.4.2AI