It sounds like you are dealing with a latency issue. You will want to open Studio One and go to Studio One>Options>Audio Setup. Here you can increase your Device Block Size. If you continue to have the issue once you have increased the Device Block Size, then you will want to check the rotational speed of your hard drive. It is recommended that you use a 7200 rpm hard drive or faster. Here is an article from Apple that explains how you can check the rotational speed of your drive.
If you continue to have an issue, you may want to submit a support ticket. Make sure that you attach your .spx file to the ticket when prompted to do so and a Presonus support agent can take a look at your system.
*If you are using a USB audio interface, then you may want to try using a different cable, different USB port, or plug directly into the computer without the use of USB Hub if you are using one. That is unless you are using a Presonus Audiobox with a USB C port.