Generally, what I do is play with the Sample Rate (higher is better in my experience) and the Buffer Size. I noticed that when I defined a larger buffer, it tends to eliminate pops and clicks (not 100%), but is much, much better.
Not sure how to get rid of pops 100%, but it's so little now for me, I can worry about getting rid of what little is less later on using a limiter or something.
I should also mention that, with my sampled instrument library sounds, I experience better responsiveness when I use a higher sampling rate. In my case, 96000 rather than 44100 and I'm using Focusrite Scarlett 2i2, Orchestral Tools Inspire I sounds, and Native Instruments Komplete S88 Mk2 controller.