Studio One 3.5 Occurs when the track is completely duplicated (along with the content in the insert). If you add a new plug-in to the duplicate track in the insert, the old plug-ins stop working. We have to re-open them.
My System: Win10x64; MB: P8Z77; Intel Core i7 3770K; 16GbDDR3SDRAM; RME Babyface.