Currently it is harder than it needs to be while working with sends. The tiny little lines as a replacement for fader and pan knob is sleek, contemporary, and elegant. But it is also not practical.
Add a console setting that changes the look of sends to more closely resemble the faders on the tracks themselves, and has vertical orientation. This makes a quick glance all you need to be able to tell how much of what you're sending where, and you won't have to have your face two inches from the screen to click on the fader to adjust the level.
Another huge problem is that you can't line up your sends like how ProTools and Logic (maybe other DAW's as well) allow you to. In those two cases, if you have multiple effects that each have multiple instruments routed to them, you can line up all the controls for effect #1 to be in the topmost position, all the controls for effect #2 to be in the second position, and so on. Then any individual track specific effects can be placed in the lower slots. This makes it easy to adjust send parameters in big projects or ones that you haven't opened in a while, since you can be 100% that if it's in slot 1, it is the delay or whatever. In Studio One however, if you only have one effect on a track it will be in the topmost position no matter what. Effectively making the above described technique of console organization impossible, since you can't have slots 1 & 2 empty so you can put the track specific send in slot 3 or lower. While a workaround is to add send tracks routed to dummy outputs, this is not ideal and will add up to huge time wastes in the long run.
If you liked this feature request, consider looking at this other one I made that outlines the super huge problems with Studio One right now that are severely holding it back from truly being one of the best DAW's out there.