These suggestions from Butch Richard at Tech Support worked for me. I think the PreSonus folder in Roaming folder was the main problem.I uninstalled Universal Control and Studio One 4. I just deleted the whole PreSonus folder from the Roaming folder, I didn't keep the agreement or back anything up. For sure do the device manager look up for hidden devices installed related to Presonus and delete them. I had done this previously and it didn't solve the problem, but I made sure to do it again. Then I Installed Universal Control and STudio One 4. Restarted. Plugged USB 96 into different USB Port. Restarted. Universal Control Automatically started on start up, I launched STudio ONe, and all is good.Follow these tips and you might be recording too!
Quit Studio One < I uninstalled Universal Control and Studio One>
Click Start and type %appdata% [Enter] to open the Roaming folder.
Open PreSonus/Studio One 4
Copy the contents of the folder to a folder on your desktop for use as a backup.
Delete all files and folders except for the user.license file < I just deleted the whole PreSonus folder>
Launch Studio One 4 and test for this issue again. If the problem still exists, please feel free to copy your settings files back over from the backup you created in step 4. < I skipped this and did the device manager look up and deleted the devices then Reinstalled>
*If you are missing any Sound Sets after doing this, simply go to Documents>Studio One>Sound Sets and double-click one of the files.
> Disconnect the AudioBox from your computer.
> Hit the Windows Key
> Now type “View advanced system settings” and press return
> Click Environment Variables button.
> Click the New button for the top section on this window.
> For "Variable Name:" type this exactly.
> For "Variable Value:" enter a single number " 1 ".
> Click OK and couple times and then open the Device Manger.
> Click the View menu and check "Show Hidden Devices".
> Right click and Uninstall any "AudioBox", "PreSonus", "USB Audio Device" and or "Unknown Device" you see listed under any category.
> Restart your computer.
> Install Universal Control again.
> Connect your Audiobox to a different USB connection on your computer.
> Restart the computer again and test the issue.