I had the exact same problem. As there were no answers anywhere on the site (and two questions about the same issue) I just started experimenting. What worked for me was going back to "my presonus" page where I originally registered the AudioBox. I downloaded the installer for "Windows 7 and above" and also clicked to have the desktop icon installed. After it finished, I clicked on the desktop icon, installed the "upgrade" (free), then restarted my computer. It worked like a champ. Hope this helps.