I use a lot of amp simulators to record electric guitars and basses and there is an old issue when monitoring almost all amp sim plugins through LLM. From the top of my head: Amplitube, S-gear, TH3, Helix Native.
The issue is you cannot hear the changes you do to a patch until you deactivate monitoring and activate it again.
If I remember correctly, it is like this because of the way Studio One and the Plugin manage automation of parameters. So the "copy" of the plugin that goes in the LLM path is not receiving the changes.