Yes reason 10 is supported. But to be honest compose your instrumentals in reason 10 bounce the wav tracks to studio one 4 professional and mix them. Less dsp plus instead of a series 3 you could get the cs18ai cheap and a studio1810 together which is a series 3 together and works in studio one 4 pro like a c24 and pro tools. That can save you money. And you can get a b.e.h.r.inger bcf2000 dirt cheap to control reason 10