The new plug-in manager in v4.5 is a start, but it seems to mostly be for showing/hiding plug-ins in the Browser. It should actually provide the ability to fully disable/blacklist selected plug-ins, so that they never even startup in S1 at all. Surely avoiding any plug-in's possible impact to S1 (e.g. crashes, slowdown, etc.) would be one of the main benefits from managing plug-ins like this.
Unless the functionality is hidden somewhere within this new window, there seems to be no way to do that.
I would also hope this could be done for more than one plug-in at a time. Right now, the plug-in manager only seems to allow updates to one plug-in at a time, which is massively time-consuming for users with a large number of plug-ins.
Access from the settings / home page, rather than having to open a track first, would be nice too!