That's what all StudioLive mixers of all generations are designed for! ;-) By default the mixers use a 1:1 routing (channel 1 -> track 1 -> channel 1 etc.), so all you need to do is selecet "USB" as input source for the channels to which the tracks are sent/routed to. Input sources can be Analog (microphone, line), USB, AVB or SD card. They are all handled in the same way.