Hi Joshua,
Studio One has a feature that ignores plugin latency. Above where your tracks are in the song view, there is a spanner symbol. Click that and a drop down menu appears. Look for the ignore plugin latency option.
Now you can set a higher block size. I record a PRS, plugged into my audio unit's instrument socket. My block size is 1024 with high dropout protection.
I hope that helps some.
Sincerely, Jake.