The AudioBox iTwo can be used with any audio application.
Keep in mind thought that on Mac OS X it will show up as an AudioBox iTwo.
However on Windows you must install the Universal Control software to get the device driver for low latency audio. This driver will help the iTwo to be recognized in different DAWs. If you don't install Universal Control (available from the download page), the AudioBox i-Two will show up as a 'Windows Audio' Device in other applications.